Custom Enzymes and Inhibitors
New England Biolabs, Inc. Shrimp Alkaline Phosphatase (rSAP) – 2500 units
Shrimp Alkaline Phosphatase (rSAP) is a heat labile alkaline phosphatase purified from a recombinant source. rSAP is identical to the native enzyme and contains no affinity tags or other modifications. rSAP nonspecifically catalyzes the dephosphorylation of 5 and 3 ends of DNA and RNA phosphomonoesters. Also, rSAP hydrolyses ribo-, as well as deoxyribonucleoside triphosphates (NTPs and dNTPs). rSAP is useful in many molecular biology applications such as the removal of phosphorylated ends of DNA and RNA for subsequent use in cloning or end-labeling of probes. In cloning, dephosphorylation prevents religation of linearized plasmid DNA. The enzyme acts on 5 protruding, 5 recessed and blunt ends. rSAP may also be used to degrade unincorporated dNTPs in PCR reactions to prepare templates for DNA sequencing or SNP analysis. rSAP is completely and irreversibly inactivated by heating at 65C for 5 minutes, thereby making removal of rSAP prior to ligation or end-labeling unnecessary.
Selleck Chemical LLC Sildenafil Citrate 25mg 171599-83-0
Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC DMXAA (Vadimezan) 25mg 117570-53-3 NSC 640488, ASA-404
DMXAA (Vadimezan) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 ?M and IC50 of 62.5 ?M in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-? but relatively low TNF-? expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Coenzyme Q10 (CoQ10) 200mg 303-98-0
Coenzyme Q10 (ubiquinone, ubidecarenone, coenzyme Q) is a component of the electron transport chain and participates in aerobic cellular respiration. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Axitinib 50mg 319460-85-0 AG 013736
Axitinib (AG 013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR? and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Bosutinib (SKI-606) 50mg 380843-75-4
Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Carboplatin 200mg 41575-94-4 JM-8, CBDCA, NSC 241240
Carboplatin (JM-8, CBDCA, NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Pfaltz & Bauer Hyaluronidase lyophilized powder bovine minimum 300 units/mg, 100mg
Hyaluronidase lyophilized powder bovine minimum 300 units/mg, 37326-33-3, MFCD00131351. 55 kDa, 100mg
Pfaltz & Bauer Trypsin Inhibitor Soy Bean| 100MG | 9035-81-8
Trypsin Inhibitor Soy Bean| 100MG | 9035-81-8
Selleck Chemical LLC Diclofenac Sodium 50mg 15307-79-6 GP 45840
Diclofenac Sodium (GP 45840) is a non-selective COX inhibitor with IC50 of 0.5 ?g/ml and 0.5 ?g/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Aprepitant 5mg 170729-80-3 MK-0869, L-754030
Aprepitant (MK-0869, L-754030) is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNF?. Aprepitant inhibits HIV infection of human macrophages. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Daptomycin 100mg 103060-53-3 LY146032
Daptomycin (LY146032) is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Saracatinib (AZD0530) 200mg 379231-04-6
Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM in cell-free assays, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Saracatinib induces autophagy. Phase 2/3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Barasertib (AZD1152-HQPA) 5mg 722544-51-6 AZD2811
Barasertib (AZD1152-HQPA, AZD2811) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay, ~3700 fold more selective for Aurora B over Aurora A. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC ABT-751 (E7010) 10mg 141430-65-1
ABT-751 (E7010) binds to the colchicine site on ?-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.